Radiation Physics and Engineering
A peer-reviewed journal published by K. N. Toosi University of Technology

Introducing a novel FDG synthesis method in Iran based on alkaline hydrolysis

Document Type : Research Article

Author

‎Parviz Ashtari

Application Radiation Research School‎, ‎Nuclear Science and Technology Research Institute‎, ‎Tehran‎, ‎Iran.

https://doi.org/10.22034/rpe.2020.57883
Abstract
‎18F-FDG PET/CT is commonly used for evaluation and diagnostic of many types of cancer‎, ‎such as; tumor diagnosis‎, ‎treatment monitoring‎, ‎and radiation therapy planning‎. ‎Accurate diagnostic is needed in meticulous patient preparation‎, ‎including restrictions of diet and activity and management of blood glucose levels in diabetic patients‎, ‎as well as an awareness of the effect of medications and environmental conditions‎. ‎All of these conditions play important roles toward obtaining good-quality images‎, ‎which are essential for accurate interpretation‎. ‎This article introduces the new synthesis and quality control method for obtaining the best quality FDG which is used as radiopharmaceutical‎. ‎All the reactions are carried out and completed in one reaction vessel without any replacement‎. ‎The paper is including details of synthesis‎, ‎quality control and transportation step‎. ‎It is the first time that the alkaline FDG synthesis is introducing by details in Iran‎.

Highlights

  • 18F-FDG PET/CT is introduced in Iran based on news synthesis according GMP.
  • It is used for diagnostic tumors, treatment monitoring and radiation therapy planning.
  • The synthesis and quality control are described in details.
  • It could be used as reference method for other PET centers.

Keywords

‎Alkaline Hydrolysis
‎Synthesis
‎FDG=[18F]Fluorodeoxyglucose‎
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Radiation Physics and Engineering
Volume 1, Issue 1
Winter 2020
Pages 7-11

  • Receive Date 09 October 2017
  • Revise Date 25 December 2017
  • Accept Date 07 January 2018

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