Introducing a novel FDG synthesis method in Iran based on alkaline hydrolysis

Document Type: Original Article


Application Radiation Research School‎, ‎Nuclear Science and Technology Research Institute‎, ‎Tehran‎, ‎Iran.


‎18F-FDG PET/CT is commonly used for evaluation and diagnostic of many types of cancer‎, ‎such as; tumor diagnosis‎, ‎treatment monitoring‎, ‎and radiation therapy planning‎. ‎Accurate diagnostic is needed in meticulous patient preparation‎, ‎including restrictions of diet and activity and management of blood glucose levels in diabetic patients‎, ‎as well as an awareness of the effect of medications and environmental conditions‎. ‎All of these conditions play important roles toward obtaining good-quality images‎, ‎which are essential for accurate interpretation‎. ‎This article introduces the new synthesis and quality control method for obtaining the best quality FDG which is used as radiopharmaceutical‎. ‎All the reactions are carried out and completed in one reaction vessel without any replacement‎. ‎The paper is including details of synthesis‎, ‎quality control and transportation step‎. ‎It is the first time that the alkaline FDG synthesis is introducing by details in Iran‎.


  • 18F-FDG PET/CT is introduced in Iran based on news synthesis according GMP.
  • It is used for diagnostic tumors, treatment monitoring and radiation therapy planning.
  • The synthesis and quality control are described in details.
  • It could be used as reference method for other PET centers.