An international journal published by K. N. Toosi University of Technology

Document Type : Research Article

Authors

1 Medical Physics Department, School of Medicine, Iran University of Medical Sciences, P.O. Box: 14155-6183, Tehran, Iran

2 Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23219, USA

10.22034/rpe.2022.323131.1050

Abstract

It is important to have accurate information regarding the dose distribution for treatment planning and to accurately deposit that dose in the tissue surrounding the brachytherapy source. However, the practical measurement of dose distribution for various reasons is associated with several problems. In this study, 6711 I-125, Micro Selectron mHDR-v2r Ir-192, and Flexisource Co-60 sources were simulated using the MCNP5 Monte Carlo method. To simulate the sources, the exact geometric characteristics of each source, the material used in them, and the energy spectrum of each source were entered as input to the program, and finally, the dosimetric parameters including dose rate constant, radial dose function, and anisotropy function were calculated for considered seeds according to AAPM, TG-43 protocol recommendation. Results obtained for dosimetric parameters of dose rate constant, radial dose function, and anisotropy function for I-125, Ir-192, and Co-60 sources agreed with other studies. According to the good agreement obtained between the parameters of TG43 and other studies, now these datasets can be used as input in the treatment planning systems and to validate their calculations.

Highlights

  • Dose rate constant was obtained for I-125, Ir-192 and Co-60 brachytherapy sources using MCNP5 code.
  • Radial dose function parameter g(r) was obtained for I-125, Ir-192, and Co-60 using MCNP5 code.
  • Anisotropy function F(r,θ) was obtained for I-125, Ir-192, and Co-60 using MCNP5 code.
  • All calculated parameters for I-125, Ir-192 and Co-60 brachytherapy sources were in consistent with reference studies.

Keywords

Main Subjects

Alizadeh, M., Ghorbani, M., Haghparast, A., et al. (2015). A Monte Carlo study on dose distribution evaluation of Flex-isource Ir brachytherapy source. Reports of Practical Oncology and Radiotherapy, 20(3):204–209.
Cross, W. G., Soares, C. G., Vynckier, S., et al. (2003). Dosimetry of beta rays and low-energy photons for brachytherapy with sealed sources, ICRU Report 72.
DeMarco, J., Solberg, T., and Smathers, J. B. (1998). A CT-based Monte Carlo simulation tool for dosimetry planning and analysis. Medical Physics, 25(1):1–11.
Dolan, J., Li, Z., and Williamson, J. F. (2006). Monte Carlo and experimental dosimetry of an brachytherapy seed. Medical Physics, 33(12):4675–4684.
Huh, H., Kim, W., Loh, J. J., et al. (2007). Rectum dose analysis employing a multi-purpose brachytherapy phantom. Japanese Journal of Clinical Oncology, 37(5):391–398.
IAEA (2000). Absorbed dose determination in external beam radiotherapy: An international code of practice for dosimetry based on standards of absorbed dose to water, IAEA technical reports series No. 398, International Atomic Energy Agency.
Kacperek, A. (2000). Clinical proton dosimetry Part I: Beam production, beam delivery and measurement of absorbed dose (ICRU Report 59).
López, J. A., Donaire, J. T., and Alcalde, R. G. (2011). Monte Carlo dosimetry of the most commonly used Ir-192 high dose rate brachytherapy sources. Rev Fis Med, 12(3):159–168.
MCNP5 (2008). MCNP5/MCNPX-exe package, Monte Carlo N-particle extended. Technical report, Los Alamos National Laboratory report.
Mostaar, A., Alahverdi, M., and Shahriari, M. (2003). Application of MCNP4C Monte Carlo code in radiation dosimetry in heterogeneous phantom.
Nath, R. (1995). Response to “Comments on Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Task Group No. 43”’ [Med. Phys. 22, 209-234 (1995)]. Medical Physics, 22(8):1351.
Rivard, M. J. (2009). Monte Carlo radiation dose simulations and dosimetric comparison of the model 6711 and 9011 brachytherapy sources. Medical Physics, 36(2):486–491.
Rivard, M. J., Coursey, B. M., DeWerd, L. A., et al. (2004). Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations. Medical Physics, 31(3):633–674.
Sadeghi, M. and Hosseini, S. H. (2010). Study of the IsoAid ADVANTAGE 125I brachytherapy source dosimetric parameters using Monte Carlo simulation. Applied Radiation and Isotopes, 68(1):211–213.
Sadeghi, M., Hosseini, S. H., and Raisali, G. (2008a). Experimental measurements and Monte Carlo calculations of dosimetric parameters of the IRA1-Pd-103 brachytherapy source.
Applied Radiation and Isotopes, 66(10):1431–1437. Sadeghi, M., Raisali, G., Hosseini, S. H., et al. (2008b). Monte Carlo calculations and experimental measurements of dosimetric parameters of the brachytherapy source. Medical Physics, 35(4):1288–1294.
Saidi, P., Sadeghi, M., Shirazi, A., et al. (2010). Monte Carlo calculation of dosimetry parameters for the IR08-brachytherapy source. Medical Physics, 37(6Part1):2509–2515.
Urie, M., Goitein, M., and Wagner, M. (1984). Compensating for heterogeneities in proton radiation therapy. Physics in Medicine & Biology, 29(5):553.
Vijande, J., Granero, D., Perez-Calatayud, J., et al. (2012). Monte Carlo dosimetric study of the Flexisource Co-60 high dose rate source. Journal of Contemporary Brachytherapy, 4(1):34–44.
Williamson, J., Coursey, B. M., DeWerd, L. A., et al. (1998). Dosimetric prerequisites for routine clinical use of new low energy photon interstitial brachytherapy sources. Recommendations of the American Association of Physicists in Medicine Radiation Therapy Committee. Ad Hoc Subcommittee of the Radiation Therapy Committee. Medical Physics, 25(12):2269–2270.